Chemical Safety
Chemical Review for Animal Protocols
The purpose of the Chemical Review is to identify significant hazards to research staff and animal care staff during dosing and study conditions under IACUC. For any chemical administered to an animal within your protocol, follow these instructions:
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Determine if the chemical is included in the List of Chemicals Requiring Review. (The List of Chemicals Requiring Review is also available in PDF Format.)
NOTE: Many chemicals routinely used in animal protocols (e.g. non-inhalant anesthetics and euthanasia solutions) are not included on this List.
Special Update:
The following do not require a Chemical Review:
- Drugs or chemicals dosed at levels to induce normal physiological effects in laboratory animals (< 75 lbs.).
- Estrogens dosed at levels below 1 mg/kg for laboratory animals.
- Androgens, progestagens, and glucocorticoids dosed at levels below 2 mg/kg for laboratory animals.
- Peptide/protein hormones - e.g., follicle stimulating hormone (FSH), chorionic gonadotropin (hCG), insulin, luteinizing hormone (LH), and thyroid stimulating hormone (TSH). Although peptide hormones may pose a health hazard in the laboratory or prior to dosing, they are degraded once they are injected into the body.
This is based on DRS Chemical Safety's discussions with University of Illinois experts in the field.
NOTE: Chemicals which are of human or biological origin (e.g., biotoxins, human-originated hCG, nonhuman primate material) may require Biological Review. See http://www.drs.illinois.edu/bss/ibc/index.aspx?tbID=ibc.
- For chemicals that require review:
- Form 1 and Form 2 do not need to be completed for chemicals that are not identified in the List of Chemicals Requiring Review unless otherwise specified by the IACUC. Contact DRS at 333-2755 if you are unsure if a chemical meets the given criteria or if there are no data available for the chemical.
NOTE: Place a copy of completed forms in your laboratory's Chemical Hygiene Plan.
NOTE: DRS reserves the right to require a laboratory inspection as a condition of Chemical Review approval.
